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Disclosure - Liability Related to the Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Financing Agreement link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Organization and Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Organization and Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Collaboration and License Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Balance Sheet Accounts (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - 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Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Organization and Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Organization and Significant Accounting Policies - Useful Lives of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Collaboration and License Agreements - Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Collaboration and License Agreements - Receivables and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Collaboration and License Agreements - Glaxosmithkline Intellectual Property (No. 3) Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Collaboration and License Agreements - Horizon Therapeutics Ireland DAC (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaboration and License Agreements - Takeda Pharmaceutical Company Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Collaboration and License Agreements - Amgen, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Balance Sheet Accounts - Summary of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Balance Sheet Accounts - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Investments - Summary of Short-term, Long-term Investments and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Intangible Assets - Expected Future Amortization (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - 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Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink