0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 0000003 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0000004 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 0000005 - Statement - Consolidated Statements of Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 0000006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 0000007 - Disclosure - Organization and Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 0000008 - Disclosure - Collaboration and License Agreements link:presentationLink link:calculationLink link:definitionLink 0000009 - Disclosure - Balance Sheet Accounts link:presentationLink link:calculationLink link:definitionLink 0000010 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Liability Related to the Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Earnings Per Share link:presentationLink link:calculationLink link:definitionLink 9954471 - Disclosure - Organization and Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9954472 - Disclosure - Organization and Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9954473 - Disclosure - Collaboration and License Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9954474 - Disclosure - Balance Sheet Accounts (Tables) link:presentationLink link:calculationLink link:definitionLink 9954475 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9954476 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9954477 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9954478 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9954479 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9954480 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9954481 - Disclosure - Earnings Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9954482 - Disclosure - Organization and Significant Accounting Policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9954483 - Disclosure - Collaboration and License Agreements - Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9954484 - Disclosure - Collaboration and License Agreements - Receivables and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9954485 - Disclosure - Collaboration and License Agreements - Glaxosmithkline Intellectual Property (No. 3) Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9954486 - Disclosure - Collaboration and License Agreements - Horizon Therapeutics Ireland DAC (Details) link:presentationLink link:calculationLink link:definitionLink 9954487 - Disclosure - Collaboration and License Agreements - Takeda Pharmaceutical Company Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9954488 - Disclosure - Collaboration and License Agreements - Amgen, Inc (Details) link:presentationLink link:calculationLink link:definitionLink 9954489 - Disclosure - Collaboration and License Agreements - Visirna Therapeutics, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9954490 - Disclosure - Balance Sheet Accounts - Summary of Property and Equipment (Detail) link:presentationLink link:calculationLink link:definitionLink 9954491 - Disclosure - Balance Sheet Accounts - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9954492 - Disclosure - Investments - Summary of Short-term, Long-term Investments and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9954493 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9954494 - Disclosure - Intangible Assets - Expected Future Amortization (Details) link:presentationLink link:calculationLink link:definitionLink 9954495 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9954496 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9954497 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954498 - Disclosure - Leases - Components of Lease Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9954499 - Disclosure - Leases - Summary of Maturities of Operating Lease Liabilities on an Undiscounted Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9954499 - Disclosure - Leases - Summary of Maturities of Operating Lease Liabilities on an Undiscounted Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9954500 - Disclosure - Leases - Supplemental Cash Flow and Other Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9954501 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954502 - Disclosure - Stock-Based Compensation - Summary of Granted and Outstanding Shares (Details) link:presentationLink link:calculationLink link:definitionLink 9954503 - Disclosure - Stock-Based Compensation - Expenses Included in Operating Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9954504 - Disclosure - Stock-Based Compensation - Summarize Information about Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9954505 - Disclosure - Stock-Based Compensation - Summary of RSUs Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9954506 - Disclosure - Fair Value Measurements - Fair Value Measurements for Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9954507 - Disclosure - Liability Related to the Sale of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9954508 - Disclosure - Earnings Per Share (Details) link:presentationLink link:calculationLink link:definitionLink